Down syndrome
noun
variants
or Down's syndrome
: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21
called also trisomy 21
Examples of Down syndrome in a Sentence
Recent Examples on the Web
Ashley Judd has signed on to star as Mari Cox in 21 Down, a film inspired by the true story of Caden Cox, who made history by becoming the first person with Down syndrome to play and score in a college football game.
—
Justin Kroll, Deadline, 7 Oct. 2025
Patton, the director and chair of TCU laboratory schools, underscored this point when asked about students with Down syndrome who are not accepted to the KinderFrogs program.
—Lina Ruiz
october 7, Fort Worth Star-Telegram, 7 Oct. 2025
The Scrubs actor — who is on the board of directors at the Global Down Syndrome Foundation (GLOBAL), a non-profit that seeks to improve all facets of life for people with Down syndrome — is dad to Max, 28, who has Down syndrome.
—Sabienna Bowman, PEOPLE, 6 Oct. 2025
Farad, who has become known and beloved to her fans over the years, has Down syndrome and is his mother’s biggest cheerleader and hype man.
—Duante Beddingfield, Freep.com, 24 Sep. 2025
See All Example Sentences for Down syndrome
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Justin Kroll, Deadline, 7 Oct. 2025
Patton, the director and chair of TCU laboratory schools, underscored this point when asked about students with Down syndrome who are not accepted to the KinderFrogs program.
—Lina Ruiz
october 7, Fort Worth Star-Telegram, 7 Oct. 2025
The Scrubs actor — who is on the board of directors at the Global Down Syndrome Foundation (GLOBAL), a non-profit that seeks to improve all facets of life for people with Down syndrome — is dad to Max, 28, who has Down syndrome.
—Sabienna Bowman, PEOPLE, 6 Oct. 2025
Farad, who has become known and beloved to her fans over the years, has Down syndrome and is his mother’s biggest cheerleader and hype man.
—Duante Beddingfield, Freep.com, 24 Sep. 2025
See All Example Sentences for Down syndrome
Cite this Entry
“Down syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Down%20syndrome. Accessed 18 Oct. 2025.
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